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KMID : 0370220040480020122
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Yakhak Hoeji
2004 Volume.48 No. 2 p.122 ~ p.129
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Effect of NDM Hair Tonic on Hair Growth Promotion in C57BL6 Mice
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남상윤/Nam SY
문준환/윤영원/백인정/연정민/류광철/이범준/Mun JH/Yun YW/Baek IJ/Yon JM/Ryu KC/Lee BJ
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Abstract
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NDM hair tonic is composed of several plant extracts which are known to be used in oriental medicine. This study was carried out to investigate the effect of NDM hair tonic on hair regrowth in an alopecia model of C57BL6 mice. Hair of six-weeks old mice were trimmed by electric clippers and electric shavers, so as not to damage the skin. The next day, mice without visible scraches were selected, randomized and separated in groups of 6 mice. There were four experimental groups including saline (negative control), 50% ethanol (vehicle control),3% minoxidil (MXD), and NDM tonic. The test compounds were topically treated with 0.15 mf per mouse per day fur 2 weeks. The hair regrowth was determined ohotographically and histologically and the quantity of endocrine factors, IGF-1 and TGF-β, in the skin of mice was measured by PCR. No clinical signs were found in all animals. The topical treatment of NDM tonic for 2 weeks to dorsal skin accelerated hair regrowth faster than either the controls or MXD treatment. The NDM tonic treatment also promoted hair follicle development and elongation as compared with the controls or MXD treatment. Both NDM tonic and MXD treatment significantly increased the expression of IGF-1 and TGF-β in the skin of C57BL6 mice as compared with the controls (p<0.05). These results suggest that NDM tonic has a hair growth activity and be useful for the treatment of baldness or alopecia.
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KEYWORD
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